SCD is a chronic hemolytic disorder characterized by the polymerization and deformation of the hemoglobin molecules within the red cells into a crescent shape. This results in vaso-occlusive events and increased hemolysis. Every year, more than 100,000 Americans are affected by SCD. High-quality treatment for people with SCD should be evidence-based and backed by clear quality measures that assess quality and enhance performance. This course provides meaningful insights into the need for preventive strategies and early interventions. It also unveils the importance of effective collaboration with healthcare and community partners in providing holistic care to SCD adults.